Some ideal properties are required for the bone scaffold. Cell, scaffold, and growth factor are the three most important conditions in tissue engineering. It has been applied to the construction of some tissues and organs such as bone, cartilage, skin, and liver. Tissue engineering, which is a promising method for the reconstruction of bone, is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes for restoring, maintaining, or improving tissue function. Bone can heal by itself when a small segment defect occurs however, despite recent advances in medical technologies, treatment of a non-healable size bone defect is still challenging. This study provides an insight into the design, analysis, and in vitro experiment of a bone tissue engineering scaffold.Īccording to recent studies, millions of people are suffering severely from orthopedic disorders caused by traffic accidents, bone tumors, infection, etc. The result shows that the inlet velocity 0.0075 m/s is suitable for cell proliferation in the scaffold. Importantly, although the mean value of wall shear stress is significantly more than 0.05 Pa, there is still a large area with a suitable shear stress below 0.05 Pa where most cells can proliferate well. Moreover, the mass flow in the bottom outlets decreases from the center to the edge, whereas the mass flow in the side outlets decreases from the top to the bottom. The mass flow in the side outlets is observed to be approximately 24.3 times higher than that in the bottom outlets in the range 6.13 × 10 −8 kg/s to 1.49 × 10 −6 kg/s. The result of this study illustrates that the pressure value drops rapidly from 0.103 Pa to 0.011 Pa in the y-axis direction and the mass flow is unevenly distributed in the outlets. The cell proliferation and the mass flow evaluated in a bioreactor further verified the flow field simulated using computational fluid dynamics. Additionally, the fluid field of the scaffolds was simulated through a numerical method based on finite volume and the cell proliferation performance was evaluated via an in vitro experiment. This method overcomes the limitations of commercially available software packages that prevent them from generating models with complex surfaces used for bone tissue engineering scaffolds. In this method, reverse engineering software was used to reconstruct the surface from point cloud data. ![]() A novel method was proposed to design the structure of a bone tissue engineering scaffold based on triply periodic minimal surface.
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